Work

The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates

Year: 2023

Type: article

Abstract: Neurologic manifestations associated with many COVID-19 patients, including acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and long COVID, have been proven by increasing evidence. 1 To date, most studies have focused on how SARS-CoV-2 invades the nervous system and the consequent neuropathological changes. 2 , 3 In contrast, the specific mechanism by which SARS-CoV-2 infection leads to neurological disease remains unclear.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-023-01386-8

Authors: Jiaxin Yang, Yan Li, Shijin Wang, Huili Li, Lili Zhang, Haichen Zhang, Pei-Hui Wang, Xiangyu Zheng, Xiao-Fang Yu, Wei Wei

Institutions: Jilin University, First Hospital of Jilin University, Shandong University, Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Long-Term Effects of COVID-19

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190

Funders: National Natural Science Foundation of China, People's Government of Jilin Province, Department of Science and Technology of Jilin Province, Fundamental Research Funds for the Central Universities, Program for Jilin University Science and Technology Innovative Research Team

Awards: G1255464089, G2168410670, G3869018770, G4426467488, G4800972335, G585547635, G6625681989

OpenAlex ID: W4323806103

FWCI: 3.358

Cites: 10

Cited by: 23

Related to: 10