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Bridging rapid and sustained antidepressant effects of ketamine

Year: 2023
Type: review
Abstract: Acute administration of (R,S)-ketamine (ketamine) produces rapid antidepressant effects that in some patients can be sustained for several days to more than a week. Ketamine blocks N-methyl-d-asparate (NMDA) receptors (NMDARs) to elicit specific downstream signaling that induces a novel form of synaptic plasticity in the hippocampus that has been linked to the rapid antidepressant action. These signaling events lead to subsequent downstream transcriptional changes that are involved in the sustained antidepressant effects. Here we review how ketamine triggers this intracellular signaling pathway to mediate synaptic plasticity which underlies the rapid antidepressant effects and links it to downstream signaling and the sustained antidepressant effects.
DOI: 10.1016/j.molmed.2023.02.003
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $6,830
Funders: Brain and Behavior Research Foundation, National Alliance for Research on Schizophrenia and Depression, Ministry of Food and Drug Safety, National Institutes of Health, Japan Society for the Promotion of Science, National Institute of Mental Health
Awards: G1719170447, G1805915753, MECP2 DEPENDENT TRANSCRIPTIONAL REPRESSION & NEUROTRANSMISSION, MeCP2 Dependent Transcriptional Repression & Neurotransmission, G3615640089, Role of SNARE Interactions in Central Synapse Function, Identification of chronic stress-related subregions in the hippocampus and its monitoring, G7257058456, G8730389166, G8923563117, G9000128908, Antidepressants and Intracellular Signaling Linked to BDNF
OpenAlex ID: W4323826024
FWCI: 1.731
Cites: 104
Cited by: 62
Related to: 10