Year: 2023
Type: article
Abstract: To the Editor: Fibrous dysplasia of the mandible and maxilla, often referred to as cherubism, begins during toddler years and culminates with involution during puberty. 1 In addition to physical disfigurement, these maxillary F I G U R E 1 (A) Giant cell granulomas of the mandible (see example marked by arrow) were present as shown on computed tomography for 5 years upon patient presentation with clinical cherubism.(B) Full resolution of the granulomas was noted both clinically and on computed tomography following 15 months of therapy with imatinib.and mandibular lesions can cause difficulty with mastication, pain, and airway compromise. 2 Mitogen-activated protein kinase pathway activation is implicated in these lesions, and while SH3 domain-binding protein 2 (SH3BP2)-associated cherubism is best known, similar lesions
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.30282
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4323920921