Discovering a change point and piecewise linear structure in a time series of organoid networks via the iso-mirror
Year: 2023
Type: preprint
Abstract: Recent advancements have been made in the development of cell-based in-vitro neuronal networks, or organoids. In order to better understand the network structure of these organoids, a super-selective algorithm has been proposed for inferring the effective connectivity networks from multi-electrode array data. In this paper, we apply a novel statistical method called spectral mirror estimation to the time series of inferred effective connectivity organoid networks. This method produces a one-dimensional iso-mirror representation of the dynamics of the time series of the networks which exhibits a piecewise linear structure. A classical change point algorithm is then applied to this representation, which successfully detects a change point coinciding with the neuroscientifically significant time inhibitory neurons start appearing and the percentage of astrocytes increases dramatically. This finding demonstrates the potential utility of applying the iso-mirror dynamic structure discovery method to inferred effective connectivity time series of organoid networks.
Source: arXiv (Cornell University)
Authors: Chen, Tianyi, Park, Youngser, Saad-Eldin, Ali, Lubberts, Zachary, Athreya, Avanti, Pedigo, Benjamin D., Vogelstein, Joshua T., Puppo, Francesca, Silva, Gabriel A., Muotri, Alysson R., Yang, Weiwei, White, Christopher M., Priebe, Carey E.
Institution: Johns Hopkins University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funder: Johns Hopkins University
OpenAlex ID: W4323921902