Prophylactic versus reactive feeding approach in patients undergoing adjuvant radiation therapy for oral cavity squamous cell carcinoma: A propensity score matched‐pair analysis
Year: 2023
Type: article
Abstract: BACKGROUND: To assess the efficacy of prophylactic versus reactive feeding strategy in oral cavity squamous cell carcinoma (OCSCC) patients receiving adjuvant radiation therapy (RT). METHODS: This was a post hoc analysis of patients of OCSCC enrolled in a randomized trial comparing three adjuvant strategies. In this trial, till 2010, a prophylactic feeding approach was followed for all patients. Since January 2011, a reactive feeding approach was followed. RESULTS: Two hundred and sixty-eight in each cohort (total n = 526) were eligible for analysis after propensity score matching. At 6 weeks post-RT completion, the median weight loss in the prophylactic versus reactive cohort was 5 versus 3 kg, p = 0.002. At all other time points until 1 year, the median weight loss was lesser in reactive than in the prophylactic cohort. CONCLUSIONS: A reactive feeding tube approach should be preferred for OCSCC receiving adjuvant RT.
Source: Head & Neck
DOI: 10.1002/hed.27336
Authors: Sarbani Ghosh Laskar, Shwetabh Sinha, Meetakshi Gupta, Shreyasee Karmakar, Meenakshi Nivedha J., Sadhana Kannan, Ashwini Budrukkar, Monali Swain, Anuj Kumar, Tejpal Gupta, Vedang Murthy, Devendra Chaukar, Prathamesh Pai, Pankaj Chaturvedi, Gouri Pantvaidya, Deepa Nair, Sudhir Nair, Shivakumar Thiagarajan, Anuja Deshmukh, Vanita Noronha, Vijay Patil, Amit Joshi, Kumar Prabhash, Jai Prakash Agarwal
Institutions: Homi Bhabha National Institute, Tata Memorial Hospital
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4324018494