O-54 Research recommendations for selected IARC-classified agents: impact and lessons learned
Year: 2023
Type: conference-abstract
Abstract: Introduction The International Agency for Research on Cancer (IARC) Monographs program assembles expert Working Groups who publish a critical review and evaluation of existing data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps and needs for 20 priority occupational chemicals, metals, dusts, and physical agents, with the goal of stimulating advances in epidemiology studies of cancer and carcinogen mechanisms. Overarching issues were also described. Materials and Methods We reviewed the current status of the relevant evidence for the 20 priority agents identified in 2009. We examined whether identified research needs for each agent were addressed, the resultant findings, and the impact on resolving classification uncertainties for any agents already re-evaluated. Information sources were either the new published Monograph for agents that have been re-evaluated; or, for agents not yet re-evaluated, authoritative reports and literature searches for new published epidemiological and human mechanistic evidence. Recent methodological developments in the Monographs evidence evaluation process were considered. Results Thirteen of the 20 priority agents were re-evaluated by IARC since 2009. The carcinogen classifications of nine agents advanced, and new cancer sites with either sufficient or limited evidence of carcinogenicity were identified for nine agents. Examination of published findings since each agent was last evaluated revealed whether evidence gaps have been addressed and highlighted remaining uncertainties. Conclusions During the past decade, new research addressed many of the 2009 recommendations, and supported updated classifications for several priority agents. This supports future efforts to systematically apply the findings of monograph reviews to the identification of research gaps and priorities, including with regard to advances in understanding mechanisms of carcinogenesis and their application in evaluation criteria established in the updated IARC Monograph preamble.
Source: Abstracts
Authors: Michelle C Turner, Elizabeth M Ward, Federica Madia, Kathryn Guyton, Kurt Straif, Mary K Schubauer-Berigan, Vincent Cogliano
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4324137780