Crosstalk between Ferroptosis and Chondrocytes in Osteoarthritis: A Systematic Review of in-vivo and in-vitro Studies
Year: 2023
Type: report
Study design: Systematic Review
Abstract: Review question / Objective: For the sake of better apprehending the nexus between ferroptosis and chondrocytes in osteoarthritis (OA), proffering novel insights and opening-up new orientation for in-depth research in both pre-clinical and clinical settings, it is warranted to initiate one rigorous and robust systematic review (SR) based upon up-to-date in-vivo and in-vitro research advances on this topic. To the best our knowledge, no SRs concerning ferroptosis and chondrocytes in OA have been published thus far. Condition being studied: Osteoarthritis (OA) is the most common form of arthritis, which menaces 7% of the human population globally. With the aged tendency of population and higher rates of obesity, the incidence of OA is anticipated to proliferate, which will entail a mounting impact and major challenges for global health care and each country’s public health systems unavoidably. In virtue of the onset of OA is mighty knotty, its etiology and underlying molecular mechanisms have not been expressly expounded. However, the salient role that cartilage degeneration acts in the progression of OA has been widely acknowledged. Chondrocytes are consequential for the safeguard of cartilage homeostasis and the functional integrity of the articular cartilage. Once the homeostatic equilibrium of the extracellular matrix (ECM) synthesis and degradation is smashed, OA comes up.
Authors: Siyang Cao, Yihao Wei, Huihui Xu, Jian Weng, Tiantian Qi, Fei Yu, Su Liu, Ao Xiong, Peng Liu, Hui Zeng
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4324145353