The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies
Year: 2023
Type: article
Abstract: Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital imaging has suggested that the expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone remodeling. These findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses. A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel interventions. To advance this understanding, herein, we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic compartment. Specifically, we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting approaches. We then discuss unresolved questions and ambiguities that remain in the field.
Source: Bone Research
Institutions: University of Rochester Medicine, University of Rochester
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
Funders: U.S. Department of Health and Human Services, National Aeronautics and Space Administration, University of Rochester, Edward P. Evans Foundation, Henry and Marilyn Taub Foundation, National Institutes of Health, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1649126679, G1707674842, G1954440393, G2120939959, G2557006295, G2696652378, G2832834015, G2956334019, G3080939237, G4102143028, G4701143036, Efferocytosis by Bone Marrow Stromal Cells and Bone Aging, G6126777226, Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesis, G6342637620, Protein modification in bone cell regulation, Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application), Quantifying the Race for the Surface via IV-MLSM, G8430399647, G8501465791, G9000004068, G9000035057, G9000103447, G9000142558, G9000173709, G9000185984, G9000219609, G9000262253, G9000277899, G9000329301, Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI), Elucidating the Mechanisms of Arthritic Flare and Developing Treatments, G988059557
OpenAlex ID: W4324153592