High-plasma soluble prorenin receptor is associated with vascular damage in male, but not female, mice fed a high-fat diet
Year: 2023
Type: article
Abstract: High-fat diet (HFD) for 28 wk leads to type 2 diabetes mellitus (T2DM) phenotype, concomitant with increased plasma soluble prorenin receptor (sPRR), nondipping blood pressure, and vascular stiffness in male mice. HFD-fed female mice exhibiting a preserved cardiometabolic phenotype until ovariectomy revealed increased plasma sPRR and blood pressure. Plasma sPRR may indicate the status of systemic renin-angiotensin-aldosterone system (RAAS) activation and the onset of vascular complications during T2DM in a sex-dependent manner.
Authors: Bruna Visniauskas, Virginia Reverte, Caleb M. Abshire, Benard O. Ogola, Carla B. Rosales, Michelle Galeas-Pena, Venkata N. Sure, Siva S. V. P. Sakamuri, Nicholas R. Harris, Isabella Kilanowski-Doroh, Alexandra B. Mcnally, Alec C. Horton, Margaret Zimmerman, Prasad V. G. Katakam, Sarah H. Lindsey, Minolfa C. Prieto
Institutions: Tulane University, Augusta University, Augusta University Health
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: American Heart Association, Fundação de Amparo à Pesquisa do Estado de São Paulo, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke
Awards: G1740413872, Translational Research in Hypertension and Renal Biology, G4180546312, G4542591229, G4958390525, Multi-user Equipament approved in grant 2017/17027-0: Microplate Reader Tecan Infinite 200 Pro, G603115684, G6164584285, G685085079, Endothelial Expression of Neuronal Nitric Oxide Synthase, Interplay of Sex Hormones and Chromosomes in Vascular Oxidative Stress and Arterial Stiffening
OpenAlex ID: W4327675426