Work

Nanosuspensions technology as a master key for nature products drug delivery and In vivo fate

Year: 2023

Type: article

Abstract: The drug nanosuspensions is a universal formulation approach for improved drug delivery of hydrophobic drugs and one the most promising approaches for increasing the biopharmaceutical performance of poorly water-soluble drug substances, especially for nature products. This review aimed to summarize the nanosuspensions preparation approaches and the main technological difficulties encountered in nanosuspensions development, such as guidelines for stabilizers screening, in vivo fate of the intravenously administrated nanosuspensions, and how to realize the intravenously target delivery was reviewed. Furthermore, challenges of nanosuspensions for the nature products delivery also was discussed and commented. Therefore, it hoped to provide reference and assistance for the nanosuspensions production, stabilizers usage, and predictability of in vivo fate and controllability of targeting delivery of the nature products nanosuspensions.

Source: European Journal of Pharmaceutical Sciences

DOI: 10.1016/j.ejps.2023.106425

Authors: Yingying Ma, Zhufeng Cong, Peng Gao, Yancai Wang

Institutions: Shandong University of Traditional Chinese Medicine, Qilu University of Technology, Shandong Academy of Sciences

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,300