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Longitudinal trajectories and determinants of plasma per- and polyfluoroalkyl substance (PFAS) levels from birth to early childhood and metabolomic associations: A pilot study in the Boston Birth Cohort.

Year: 2022
Type: article
Abstract: Background: Per- and polyfluoroalkyl substances (PFAS) are a major public health concern worldwide due to their ubiquitous exposures, environmental persistence, maternal-to-fetal transfer, and multi-organ toxicity. This pilot study aimed to generate preliminary data to inform future studies to address data gaps in the field, including early life PFAS exposure levels, longitudinal changes, determinants, and associated metabolomic alterations in understudied Black and Hispanic children in the United States (U.S.). Methods: This study leveraged existing biosamples and data in the Boston Birth Cohort and measured 12 legacy and emerging PFAS, including Me-PFOSA-AcOH, PFDA, PFDoA, PFHxS, PFNA, PFOA, PFOS, PFUnA, GenX, ADONA, 9Cl-PF3ONS, and PFHpS, in paired cord and early childhood plasma samples. Summary statistics and graphic plots were used to depict PFAS levels at the two time points and their longitudinal changes. Linear regression models were used to identify the early-life factors associated with cord and early childhood PFAS levels. Associations of cord PFAS with cord metabolites were explored using a metabolome-wide association approach and a targeted approach. Results: PFAS exposure. Conclusions: PFAS exposures may alter fetal metabolism. Future large-scale studies are needed to replicate the findings and further examine the associations of fetal PFAS exposure with long-term health outcomes and underlying metabolic pathways.
Source: PubMed
Authors: Mingyu Zhang, Chang Ho Yu, Guoying Wang, Jessie P Buckley, Xiumei Hong, Colleen Pearson, William G Adams, Zhihua Tina Fan, Xiaobin Wang
Institutions: Johns Hopkins University, New Jersey Department of Health, Boston University, Boston Medical Center, Johns Hopkins Medicine, Johns Hopkins Hospital
Language: English
Open Access status: green
Funders: American Heart Association, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Environmental Health Sciences, Maternal and Child Health Bureau, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Early Life Phthalate and Perfluoroalkyl Substance Exposures and Childhood Bone Health, Maternal Exposure to Low Level Mercury, Metabolome, and Child Cardiometabolic Risk in Multi-Ethnic Prospective Birth Cohorts, Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth Cohort, Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth Cohort, Functional RNA Modifications, Micronutrient Exposure, Developmental Disabilities, Preterm Birth and Child Long-term Cardiometabolic Risk: Integrate Proteomics with Birth Cohort, Endocrine disrupting chemical mixtures and bone health in adolescence
OpenAlex ID: W4327900247
FWCI: 1.411
Cites: 58
Cited by: 17
Related to: 10