Work

A Role for Second Messengers in Axodendritic Neuronal Polarity

Year: 2023

Type: review

Abstract: Neuronal polarization is a complex molecular process regulated by intrinsic and extrinsic mechanisms. Nerve cells integrate multiple extracellular cues to generate intracellular messengers that ultimately control cell morphology, metabolism, and gene expression. Therefore, second messengers' local concentration and temporal regulation are crucial elements for acquiring a polarized morphology in neurons. This review article summarizes the main findings and current understanding of how Ca2+, IP3, cAMP, cGMP, and hydrogen peroxide control different aspects of neuronal polarization, and highlights questions that still need to be resolved to fully understand the fascinating cellular processes involved in axodendritic polarization.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.1065-19.2023

Authors: Pamela J. Urrutia, Christian González-Billault

Institutions: Universidad San Sebastián, University of Chile, Buck Institute for Research on Aging

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: Agencia Nacional de Investigación y Desarrollo, Comisión Nacional de Investigación Científica y Tecnológica, Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias