Year: 2023
Type: article
Abstract: significantly delayed leukemogenesis and prolonged survival.Future studies will need to understand whether type 1 interferon signaling can be leveraged therapeutically for treatment of pediatric FLT3-ITD mutant AML.In summary, the functional output of FLT3-ITD signaling is dynamic and has age-, cell-type-, and co-mutation-specific dependencies.This lesson in FLT3-ITD signaling will not soon be forgotten and will affect how we think about responsiveness to TKIs and other therapies in the future in different FLT3-ITD mutant AML subtypes.
Source: Blood
Author: Andrew Yee
Institution: Baylor College of Medicine
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4360600333