Work

A mitochondria-targeting self-assembled carrier-free lonidamine nanodrug for redox-activated drug release to enhance cancer chemotherapy

Year: 2023

Type: article

Abstract: and pro-apoptotic Bax, and downregulate anti-apoptotic Bcl-2. Generally, Cy-TK-LND NPs exhibit efficient mitochondria-targeted delivery to improve the medicinal availability of LND. Accordingly, such a carrier-free prodrug-based nanomedicine holds promise as an effective cancer chemotherapy strategy.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d2tb02728c

Authors: Ting Yang, Xianfen Zhang, Xing Yang, Ying Li, Jingjing Xiang, Chunbai Xiang, Zhongke Liu, Luo Hai, Saipeng Huang, Lihua Zhou, Ruijing Liang, Ping Gong

Institutions: Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, University of Chinese Academy of Sciences, Northwest University, University of Science and Technology of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Shenzhen City Polytechnic

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Shenzhen Science and Technology Innovation Program

Awards: G1075100148, G1872468139, G1986041887, G7409481675, G8332570486

OpenAlex ID: W4360779090

FWCI: 0.886

Cites: 49

Cited by: 16

Related to: 10