Work

Charge shielding effects of PEG bound to NH 2 -terminated PAMAM dendrimers – an experimental approach

Year: 2023

Type: article

Abstract: H-NMR, allows us to study more closely the non-covalent interactions between PEG and PAMAM. We find that increasing PEG chain length increases the number of non-covalent interactions. Additionally, at low grafting densities, increasing the number of PEG chains on the PAMAM surface also increases the non-covalent interactions. At higher grafting densities, however, PEG chains sterically repel one another, forcing chains to elongate away from the surface and reducing the number of interactions between PAMAM and individual PEG chains. The data presented here provides a framework for a more precise mechanistic understanding of how the length and density of tethered PEG chains on PAMAM dendrimers influence drug delivery properties.

Source: Soft Matter

DOI: 10.1039/d2sm01698b

Authors: Brandon M. Johnston, Alan J. Grodzinsky, Paula T. Hammond

Institutions: Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: U.S. Department of Defense, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Congressionally Directed Medical Research Programs

Awards: Multivalent Nano-conjugates for Targeted Penetration of and Delivery to Dense Extracellular Matrices, Cartilage-Penetrating Nanocarrier-Drug Conjugate for Disease-Modifying Intervention in Post-Traumatic Osteoarthritis