Work

A canine model of chronic ischemic heart failure

Year: 2023

Type: article

Abstract: The novel total left anterior descending devascularization (TLD) approach in a canine ischemic heart failure model limits collateral flow in the ischemic zone and provides excellent early survival and repeatable development of chronic ischemic heart failure in the canine heart. This work provides a consistent large animal model for investigating heart failure mechanisms and testing novel therapeutics.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00647.2022

Authors: Muhammad S. Khan, Douglas Smego, Yuki Ishidoya, Annie M. Hirahara, Emmanuel Offei, Martha S. Ruiz Castillo, Omar Gharbia, Hui Li, Joseph A. Palatinus, Lauren Krueger, TingTing Hong, Guillaume L. Hoareau, Ravi Ranjan, Craig H. Selzman, Robin M. Shaw, Derek J. Dosdall

Institution: University of Utah

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Nora Eccles Treadwell Foundation, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences

Awards: Novel lead for selective His bundle sensing and low-threshold pacing, Antitachycardia pacing and improved lead for ventricular conduction system stimulation, Advancing cBIN1 Therapy to Large Preclinical Animals, Institutional Career Development Core, Utah Center for Clinical and Translational Science, Unlocking Trafficking Specificity for Cx43 Gap Junctions, Regulation of Cav1.2 Trafficking by GJA1-20k and cBIN1, CTSA UM1 Program at University of Utah, Training in Cardiovascular Research

OpenAlex ID: W4360805144

FWCI: 1.769

Cites: 40

Cited by: 9

Related to: 10