Work

Aneuploidy Is Associated with Azole Resistance in Aspergillus fumigatus

Year: 2023

Type: article

Abstract: Azole resistance in Aspergillus fumigatus is on the rise. Nontarget-mediated mechanisms are a common cause of azole resistance in chronic pulmonary aspergillosis (CPA).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01253-22

Authors: Aiah Khateb, Sara Gago, Michael Bromley, Malcom Richardson, Paul Bowyer

Institutions: King Abdulaziz University, Taibah University, University of Manchester, Manchester University NHS Foundation Trust

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Pfizer, Gilead Sciences, Wellcome Trust, National Institute for Health and Care Research, European Commission, National Institutes of Health, Manchester Biomedical Research Centre, Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: G339059223, Understanding and mitigating the impact of emerging antifungal resistance, Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system, The Aspergillus fumigatus gene and non-coding RNA knockout library, A genome-scale census of virulence factors in the major mould pathogen of human lungs, Elevated gene transcription of the cyp51A gene is essential for azole drug resistance in Aspergillus fumigatus

OpenAlex ID: W4361190137

FWCI: 2.523

Cites: 18

Cited by: 13

Related to: 10