Body Composition Changes Over the Menopausal Transition in Women With and Without Human Immunodeficiency Virus
Year: 2023
Type: article
Abstract: BACKGROUND: Women are at risk for weight gain during the transition to menopause, but few have examined the contribution of menopause to weight gain in women with human immunodeficiency virus (WWH). METHODS: From 2000 to 2013, participants (621 WWH; 218 without HIV [WWOH]) from the Women's Interagency HIV Study were categorized by menopausal phase using serial measures of anti-Müllerian hormone (AMH). Multivariable linear mixed models examined the association of menopausal phase with body mass index (BMI) and waist circumference (WC) trajectory, stratified by HIV status. RESULTS: In models controlled for chronologic age, the estimated effects (95% confidence interval) of menopausal phase on annual rate of BMI change across early perimenopause, late perimenopause, and menopause, respectively, compared to premenopause were -0.55% (-.80 to -.30), -0.29% (-.61 to .03), and -0.67% (-1.12 to -.20) in WWH, whereas estimated effects were 0.43% (-.01 to .87) and 0.15% (-.42 to .71) across early and late perimenopause, respectively, and -0.40% (-1.24 to .45) across menopause in WWOH. The estimated effects on rate of WC change were negative across early perimenopause (-0.21% [-.44 to .03]) and menopause (-0.12% [-.5 to .26]) and positive across late perimenopause (0.18% [-.10 to .45]) in WWH, and positive across all 3 menopausal phases in WWOH, but these effects were not statistically significant. CONCLUSIONS: In WWH, the menopausal transition was associated with BMI and WC trajectories that were mostly in a negative direction and opposite from WWOH after adjusting for age, suggesting that HIV blunts weight gain during the menopausal transition.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciad165
Institutions: University of California, San Francisco, Brown University, John H. Stroger, Jr. Hospital of Cook County, Cook County Health and Hospitals System, Albert Einstein College of Medicine, SUNY Downstate Health Sciences University, Georgetown University Medical Center, San Francisco VA Medical Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, Eli Lilly and Company, Gilead Sciences, Emory University, Northwestern University, Johns Hopkins University, Northern California Institute for Research and Education, Georgia Clinical and Translational Science Alliance, National Institutes of Health, University of California, Los Angeles, Center for AIDS Research, University of Washington, University of California, San Francisco, Center for AIDS Research, University of Alabama at Birmingham, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, Office of AIDS Research, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Clinical and Translational Science Institute, University of California, San Francisco, Center for AIDS Research, University of North Carolina at Chapel Hill, Liver Center, University of California, San Francisco
Awards: G1034546755, G1296759572, G1329112180, G1787625665, G1849940085, G1913134163, G1978185739, G2008237588, G208418196, HIV, HCV, and gender effects on Liver, Bone, and Vascular Health, G259661504, G2908277772, G311558797, G3630727822, G3869857964, G4016133911, G4044828089, G4053245312, G4391827178, G4448937686, G4535678174, G4889872267, G5147848267, G521591464, G5660189159, G5863844756, Clinical and Translational Science Institute, G5900455136, G6396423216, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G7152846654, Johns Hopkins Institute for Clinical and Translational Research, HIV, HCV and the Menopausal Transition: Effects on Steatosis and Fibrosis Progression, G9000082816, University of Pittsburgh MACS/WIHS CCS, MACS/WIHS -CCS, Training in HIV Translational Research, UCSF Liver Center, SF Bay Area MACS/WIHS Combined Cohort Study, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Center for AIDS Research at Emory University, Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research, Los Angeles CRS for the MACS/WIHS Combined Cohort Study, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study, MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS), The University of North Carolina Center for AIDS Research, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site, UAB-MISS MACS/WIHS Combined Cohort Study, Miami Center for AIDS Research, UCLA Clinical and Translational Science Institute, Clinical and Translational Science Institute, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4361190344