Year: 2023
Type: article
Abstract: INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias. METHODS: The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry. RESULTS: During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13020
Authors: Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Piña‐Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia TCW, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C. Carrillo
Institutions: Alzheimer's Association, Brigham and Women's Hospital, Harvard University, Columbia University Irving Medical Center, Columbia University, Mayo Clinic, Mayo Clinic in Florida, University of Miami, University of Kentucky, Icahn School of Medicine at Mount Sinai, German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology, Ludwig-Maximilians-Universität München, University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Rutgers, The State University of New Jersey, Rutgers Health, Duke University, Yale University, Georgetown University, University of Pittsburgh, New York University, Broad Institute, Boston Children's Hospital, Stanley Center for Psychiatric Research, Stockholm University, Albert Einstein College of Medicine, University of North Texas Health Science Center, University of California, San Francisco, Global Brain Health Institute, Boston University, Massachusetts General Hospital, Banner Health, Banner Alzheimer’s Institute, University of Florida, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Emory University, University of California, Los Angeles, Sahlgrenska University Hospital, UK Dementia Research Institute, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, University College London, University of Gothenburg
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Funders: Alzheimer's Association, Parkinson's Disease Foundation, Infectious Diseases Society of America, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Eye Institute, National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities
Awards: G10677868, Genomic approach to identification of microglial networks involved in Alzheimer disease risk, Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD, G1603899135, G181977427, G1936220471, G2054967980, Asian Resource Centers for Minority Aging Research (RCMAR), G2243934053, G2423438852, G2582322178, G261300933, ApoE pathway in cerebrovascular Aβ clearance in Alzheimer's disease, Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans., G266544023, ApoE pathway in cerebrovascular Aβ clearance in Alzheimer's disease, G2810311969, G2835848116, G3112572017, Physical exercise and Blood-brain communication: exosomes, Klotho and choroid plexus, G3286321079, The role of peripheral myeloid cells in Alzheimers disease, G3819873610, G3841309259, G392557602, Impact of ApoE2 on aging-related conditions, G4497909267, Binge Drinking in Couples and Intimate Partner Violence, G4953209828, Investigating the convergence of AD genetics on lipid metabolism and microglia regulation, Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease, G6680161983, G708146995, G714069824, ApoE isoform-specific therapy for Alzheimer disease, G744913063, G745744428, ApoE isoform-specific therapy for Alzheimer disease, G7868001063, G8310865787, Mechanisms of Cellular Immortalization, Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease, Arizona Alzheimer's Disease Research Center, APOE in the Predisposition to, Protection from and Prevention of Alzheimer's Disease, Biology and pathobiology of apoE in aging and Alzheimer's disease, ncRNAs in plasma EVs of AD patients and their discriminatory power as biomarkers, G912335575, G92663914, AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Abeta Antibody to Avoid Vascular Side Effects
OpenAlex ID: W4361191189