Supplementary Figure S1-S6 from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors
Year: 2023
Type: supplementary-materials
Abstract: Figure S1 Preparation experiments for CRIPSR screening. Figure S2 Quality control of the result of CRISPR screening. Figure S3 Validation experiments with PC9 or HCC827 cells transduced sgRNAs targeting ufmylation. Figure S4 ER stress pathway response involve in the phenotypic change of the PC9 cells in the abcense of ufmylation. Figure S5 Inflammation pathway activation affect the status of cancer cells through modifying the apoptosis pathway. Figure S6 Bcl-xL dependency in the cells with increased ER stress
Authors: Hideki Terai, Shunsuke Kitajima, Danielle S. Potter, Yusuke Matsui, Laura Gutierrez Quiceno, Ting Chen, Tae-jung Kim, Maria Rusan, Tran C. Thai, Federica Piccioni, Katherine A. Donovan, Nicholas Kwiatkowski, Kunihiko Hinohara, Guo Wei, Nathanael S. Gray, Eric S. Fischer, Kwok-Kin Wong, Teppei Shimamura, Anthony Letai, Peter S. Hammerman, David A. Barbie
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361234409