Supplementary figures and methods from Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy
Year: 2023
Type: supplementary-materials
Abstract: Supplementary figures 1-6 and supplementary methods. S1, EGFR and CD3 profiles of the cell lines used in the study; S2, cBiTE antibodies are expressed from ICO15K-cBiTE-infected cells and specifically bind to target cells; S3, Characterization of adenovirus infection in A431 cells; S4. Preactivated T cells produce proinflammatory cytokines and show higher killing capacities than naïve T cells when engaged by the cBiTE; S5, Luciferase- and GFP-expressing T cells retain their proliferative capacities in vitro; S6, Immunohistological detection of adenovirus and cBiTE in tumor samples.
Authors: Carlos Alberto Fajardo, Sonia Guedan, Luis Alfonso Rojas, Rafael Moreno, Marcel Arias-Badia, Jana de Sostoa, Carl H. June, Ramon Alemany
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361235485