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Supplementary Figures S6 -S11 from DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer

Year: 2023

Type: supplementary-materials

Abstract: Figure S6: Association of DDB2, TCF4 and β-catenin on Rnf43 upstream region and intron regions.Figure S7: EZH2 and PAF are required for Rnf43 expression.Figure S8: DDB2 is required for the RNF43-mediated sequestration of TCF4 to the nuclear membrane.Figure S9: WES showed missense mutation in Ctnnb1 gene.Figure S10: DDB2 regulates RNF43 and Wnt target gene expression in normal colonic tissues.Figure S11: Model of how DDB2 regulates Wnt pathway and colon cancer development through RNF43.

DOI: 10.1158/0008-5472.22416393.v1

Authors: Shuo Huang, Damiano Fantini, Bradley J. Merrill, Srilata Bagchi, Grace Guzman, Pradip Raychaudhuri

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361235856

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