Work

Supplementary Fig. 4 from Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models

Year: 2023

Type: supplementary-materials

Abstract: PET/CT whole body image of [18F]PARPi 2 h p.i. Whole body PET/CT images of tumor bearing ntv-a;p53fl/fl mice. The brain tumor can clearly be distinguished from background brain signal. In the body, high uptake can be seen especially in the gut. This is due to the hepatobiliary excretion of the molecule, caused by its high lipophilicity which is necessary in order to reach the target in the cell nucleus.

DOI: 10.1158/0008-5472.22416194

Authors: Susanne Kossatz, Brandon Carney, Melanie Schweitzer, Giuseppe Carlucci, Vesselin Z. Miloushev, Uday B. Maachani, Prajwal Rajappa, Kayvan R. Keshari, David Pisapia, Wolfgang A. Weber, Mark M. Souweidane, Thomas Reiner

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361235986

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