Work

Supplementary Fig. 3 from Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models

Year: 2023

Type: supplementary-materials

Abstract: Histological characterization of GEMM tumor model and PARPi-FL localization. (a) The GEMM model showed heterogenous morphological characteristics, representing high grade areas (with necrotic features, high cellularity, microvascular proliferation) and lower grade areas (less cellular, no necrosis). PARP1 expression was more pronounced in high grade areas compared to low grade areas and very low in normal pons. (b) Immunofluorescent characterization of high grade and low grade tumor areas and healthy brain. Tissues were stained for Ki67, CD31 and PARP1 expression. This was compared to the localization of intravenously in vivo injected PARPi-FL.

DOI: 10.1158/0008-5472.22416197

Authors: Susanne Kossatz, Brandon Carney, Melanie Schweitzer, Giuseppe Carlucci, Vesselin Z. Miloushev, Uday B. Maachani, Prajwal Rajappa, Kayvan R. Keshari, David Pisapia, Wolfgang A. Weber, Mark M. Souweidane, Thomas Reiner

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361236078

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