Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Year: 2023
Type: supplementary-materials
Abstract: Figure S1: Loss of Rictor does not prevent pancreatic formation or function. Figure S2: Rictor deletion decreases proliferation in PanIN1 lesions. Figure S3: Rictor deletion alters CDKI and BMI1 expression and localization. Figure S4: Rictor deletion does not affect response to caerulein-induced pancreatic injury. Figure S5: Absence of mTORC2 activity increases the nuclear expression of CDKIs in PanIN1 lesions driven by KrasG12D and caerulein-induced pancreas injury. Figure S6: Rictor knockdown impairs the transformed phenotype in murine PDAC cells. Figure S7: AZD2014 treatment blocks signaling downstream of mTORC1 and mTORC2. Figure S8: AZD2014 and AZD8186 co-treatment blocks downstream mTORC2 targets.
Authors: David R. Driscoll, Saadia A Karim, Makoto Sano, David M. Gay, Wright Jacob, Jun Yu, Yusuke Mizukami, Aarthi Gopinathan, Duncan I. Jodrell, T.R. Jeffry Evans, Nabeel Bardeesy, Michael N. Hall, Brian J. Quattrochi, David S. Klimstra, Simon T. Barry, Owen J. Sansom, Brian C. Lewis, Jennifer P. Morton
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361237245