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Supplementary Figure S2 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S2 MiR-424 drives an intermediate EMT that does not repress epithelial programming. (A) Phase contrast images of SUM149PT cells stably expressing miR-424 and (B) miR-200c levels, by qPCR. MCF12A cells stably expressing miR-424 examined for (C) N-cadherin protein, (D) morphology and (E) miR-424 levels and (F) EMT markers, by qPCR. HMLE cells stably expressing miR-424 examined for (G) morphology, (H) miR-424 levels and (I) EMT markers, by qPCR, and (J) N-cadherin protein. SEM shown, n{greater than or equal to}3. *p<0.05, **p<0.01, ***p<0.001, two-tailed unpaired t-test. Bar-100 μm.

DOI: 10.1158/0008-5472.22406477

Authors: David J. Drasin, Anna L. Guarnieri, Deepika Neelakantan, Jihye Kim, Joshua H. Cabrera, Chu-An Wang, Vadym Zaberezhnyy, Pierluigi Gasparini, Luciano Cascione, Kay Huebner, Aik-Choon Tan, Heide L. Ford

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361238271

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