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supplemental figure 3 from RETRACTED: Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells

Year: 2023

Type: supplementary-materials

Abstract: SUPPL FIG 3: A) Relative DEPTOR expression in MMCLs and hepatocellular carcinoma (HCC) cell lines in a representative experiment (upper panel) and means+/-SD of 3 experiments (lower bar graph); B) Relative sensitivity of U266 and FR4 MMCLs vs DEPTOR-expressing JHH7, HUH-1 or HIH7 HCCs; data are means +/- SD (n=3); Asterix demonstrates significant (p<0.05) decreased cell survival in MMCLs vs HCC cells ; C) MMCLs or HUH-1 HCC cells following shRNA transfection with control (scramble) or DEPTOR-targeted lentivirus; D) Percent apoptosis at 3 or 4 days following DEPTOR silencing in MMCLs or HUH-1 HCC; Data are means +/- SD, n=4 following transfection with control shRNA (scr) or shRNA targeting 2 separate sequences of DEPTOR.

DOI: 10.1158/0008-5472.22410366

Authors: Yijiang Shi, Tracy R. Daniels-Wells, Patrick Frost, Jihye Lee, Richard S. Finn, Carolyne Bardeleben, Manuel L. Penichet, Michael E. Jung, Joseph Gera, Alan Lichtenstein

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361238273

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