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Supplementary Movie 4 from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

Year: 2023

Type: supplementary-materials

Abstract: MOV file - 868K, Supplementary Movie 4. Inhibitory Anti-Beta1 Integrin mAb OS2966 Disrupts BRG3 Adhesion, Spreading, And Migration. Related to Figure 2. Timelapse phase-contrast imaging of BRG3 bevacizumab-resistant cells on fibronectin demonstrates mesenchymal migration of control (10 μg/ml IgG, left) cells into the wound in a scratch wound healing assay. In contrast, BRG3 cells in the treatment condition (10μg/ml OS2966, right) rapidly lose adhesive contacts to the substrate (within 20-30 mins) and are unable to migrate into the wound. Movie images captured with a 40x objective representing approximately 10 hours of imaging, 35 minutes between each frame.

DOI: 10.1158/0008-5472.22394382

Authors: W. Shawn Carbonell, Michael DeLay, Arman Jahangiri, Catherine C. Park, Manish K. Aghi

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361240768

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