Supplementary Figure 7 from Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions
Year: 2023
Type: supplementary-materials
Abstract: Figure S7. Bioinformatic analysis of TUG1-sponged miRNAs and mRNA targets in CML. A, (left) Integration of validated TUG1-sponged miRNAs with RNAseq data (heatmaps) from BM CD34+CD38- and CD34+CD38+ CML (CP and BC) and NBM (n=3/group). Effect of TUG1-sponged miRNA on PP2A inhibitors (Venn diagram); Functional integration of TUG1-sponged miRNAs and their mRNA targets into regulatory network KEGG/GO analysis; (right) Circular diagrams show top 4 pathways affected by TUG1-sponged miRNAs. B, Predicted effect of MIR300 and of TUG1-sponged miRNAs on Pluripotent Stem Cell Signaling pathways.
Authors: Giovannino Silvestri, Rossana Trotta, Lorenzo Stramucci, Justin J. Ellis, Jason G. Harb, Paolo Neviani, Shuzhen Wang, Ann-Kathrin Eisfeld, Christopher J. Walker, Bin Zhang, Klara Srutova, Carlo Gambacorti-Passerini, Gabriel Pineda, Catriona H. M. Jamieson, Fabio Stagno, Paolo Vigneri, Georgios Nteliopoulos, Philippa C. May, Alistair G. Reid, Ramiro Garzon, Denis-Claude Roy, Moutuaata M. Moutuou, Martin Guimond, Peter Hokland, Michael W. Deininger, Garrett Fitzgerald, Christopher Harman, Francesco Dazzi, Dragana Milojkovic, Jane F. Apperley, Guido Marcucci, Jianfei Qi, Katerina Machova Polakova, Ying Zou, Xiaoxuan Fan, Maria R. Baer, Bruno Calabretta, Danilo Perrotti
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361246626