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Supplementary Figure S1-7 from Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Year: 2023
Type: supplementary-materials
Abstract: Fig. S1. Importance of mutant KRAS status for cellular and clinical radioresistance. Fig. S2. Characterization of the CSC-like features of KRAS mutant NSCLC cells. Fig. S3. Pathway analysis of differentially expressed genes in KRAS mutant vs wild-type NCI-H1703 cells. Fig. S4. Factors influencing the radioresistance of NSCLC cell lines with mutant KRAS. Fig. S5. Role of SPP1/osteopontin expression in KRAS mutant and wild-type NSCLC cell lines and tumors. Fig. S6. Characterization of MLCC alterations in KRAS mutant NSCLC. Fig. S7. BIM regulation and importance of p53/p16 alterations in KRASmut NSCLC.
DOI: 10.1158/0008-5472.22416845.v1
Authors: Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
OpenAlex ID: W4361256707
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