Work

Supplemental Figures 5-8 from Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure 5 PARPi sensitivity of BRCA1 short hairpin (shBRCA1)-knockdown cells. Supplementary Figure 6 TCGA analysis of MYC and DNA repair pathway. Supplementary Figure 7 Immunohistochemical analysis of a TNBC patient cohort before and after chemotherapy. Supplementary Figure 8 Inhibition of MYC expression (via siMYC) in TNBC cell lines (MB231 and SUM149).

DOI: 10.1158/0008-5472.22417127

Authors: Jason. P.W. Carey, Cansu Karakas, Tuyen Bui, Xian Chen, Smruthi Vijayaraghavan, Yang Zhao, Jing Wang, Keith Mikule, Jennifer K. Litton, Kelly K. Hunt, Khandan Keyomarsi

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361256757

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