Supplementary Figure legends from Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Year: 2023
Type: supplementary-materials
Abstract: This file contains a detailed experimental description for the Supplementary Figure legends. Briefly, Supplementary Figure 1 describes the effects of the anti-Jagged therapy in the distribution of CD31+ cells in tumors. Supplementary Figure 2 summarizes the sorting strategy by flow cytometry to identify cancer cells and myeloid cells. Supplementary Figure 3 defines the effects of the anti-Gr-1 therapy on MDSCs and MDSC-LC in tumors. Supplementary Figure 4 illustrates the effect of anti-Jagged on immunogenic antigen-presenting cells. Supplementary Figure 5 shows that anti-Jagged increases the function of antigen-specific T-cells. Supplementary Figure 6 defines the effects of the tumor-derived factors on the expression of Jagged molecules on MDSCs.
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361257481