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Supplementary Figure S7 from Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Fig. S7. A. Principal component analysis (PCA), and B. Hierarchical Clustering (HCL) Analysis showing distinct difference between transcript profile of siCtrl- and siHuR-transfected A2780 cells. C and D. MA plots of gene expression of 163 genes following transfection of A2780 cells with siHuR and with siCtrl. C. 66 genes were significantly down-regulated and 50 genes were significantly up-regulated when HuR was knocked down. D. 37 significantly down-regulated genes (56%) are direct HuR targets (i.e., HuR binds to their mRNA transcript); 31 significantly up-regulated genes (62%) are direct HuR targets.

DOI: 10.1158/0008-5472.22410695

Authors: Yu-Hung Huang, Weidan Peng, Narumi Furuuchi, Jacquelyn Gerhart, Kelly Rhodes, Neelanjan Mukherjee, Masaya Jimbo, Gregory E. Gonye, Jonathan R. Brody, Robert C. Getts, Janet A. Sawicki

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361257846

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