Supplementary Figures 1 - 8 from IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 669KB, Supplemental Figures 1-8 with annotation S1. siRNA titration in MCF-7 cells. S2. IGF-I induced xCT mRNA and protein expression specifically through IRS-1 in T47D and ZR-75-1 cells. S3. Inhibition of IGF- signaling. S4. Effect of SASP, BSO, and NAC concentration on growth. S5. IGF-I regulated intracellular ROS level via xC- transporter in MCF-7 and T47D cells but not in MDA-MB-231 cells. S6. xCT shRNA downregulation in MCF-7 cells. S7. Ligands of the insulin/IGF system stimulated xCT mRNA expression but not CD44v mRNA expression in MCF-7 cells. S8. BSO mediated cellular behaviors assays in MCF-7 cells.
Authors: Yuzhe Yang, Douglas Yee
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361258453