Supplementary Figures 1 - 7 from Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 709K, Figure S1. Correlation of relative mean fold changes in expression of genes and microRNAs of the mouse tumor groups by expression- array and by quantitative RT-PCR. Figure S2. Levels of caspase-8 protein in primary tumors and BM secondary tumors. Figure S3. Primary tumors from wild-type or caspase-8 deficient (fl/ko, fl/fl or wt/ko caspase-8) mice had neuroblastoma morphology and stained positive for neuronal markers typical for neuroblastoma. Figure S4. Age at maximum tumor burden of neuroblastoma primary tumors in the Th-MYCN mouse groups. Figure S5. Measuring apoptosis levels by immunostaining for cleaved caspase-3. Figure S6. MYCN expression in the primary Th-MYCN, Th-Cre neuroblastoma tumors. Figure S7. Secondary tumors observed in both the Th-MYCN Caspase-8 wt/wt and the Th-MYCN deficient caspase-8 mouse models.
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361258778