Work

Supplementary Movie 2 from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

Year: 2023

Type: supplementary-materials

Abstract: MOV file - 1367K, Supplementary Movie 2. Beta1 Integrin Knockdown Impairs BRG Migration. Related to Figure 2. Timelapse phase-contrast imaging of BRG3 bevacizumab-resistant cells on fibronectin demonstrates mesenchymal migration of control (shCTRL, left) cells into the wound in a scratch wound assay. In contrast, migration of beta1 knockdown cells (shB1-c6, right) is significantly attenuated . As in Supplementary Movie 1, knockdown cells demonstrate impaired ability to spread upon the fibronectin substrate (rounded, phasebright cells). Movie images captured with a 40x objective representing approximately 16 hours of imaging, 35 minutes between each frame.

DOI: 10.1158/0008-5472.22394388

Authors: W. Shawn Carbonell, Michael DeLay, Arman Jahangiri, Catherine C. Park, Manish K. Aghi

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361260907

Cites:

Cited by:

Related to: 10