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Supplemental Figure 4 from Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: A. LCC9 breast cancer cells were transfected with control siRNA, GRP78 siRNA, control pcDNA, or GRP78 cDNA for 72 hours and CD47, calreticulin, and HMGB1 protein expression measured by Western blot hybridization. B. LCC9 xenografts from control mice or mice treated with TAM, GRP78M, or GRP78M+TAM were stained for CD47 and visualized at 20X. n=6; *p<0.05.

DOI: 10.1158/0008-5472.22408503

Authors: Katherine L. Cook, David R. Soto-Pantoja, Pamela A.G. Clarke, M. Idalia Cruz, Alan Zwart, Anni Wärri, Leena Hilakivi-Clarke, David D. Roberts, Robert Clarke

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361804989

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