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Supplementary Figure 3 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 128K, Target engagement was validated for several cell lines via western blot analyses. Here, RPE-1, SK-N-AS, KELLY and NB-1691 cells are shown following treatment with increasing concentrations of MK-8776 and MK-1775 for 16h. Inhibition of Chk1 (via MK-8776) and Cdc2 phosphorylation (via MK-1775) was observed in sensitive cell lines

DOI: 10.1158/0008-5472.22399256

Authors: Mike R. Russell, Kirill Levin, JulieAnn Rader, Lili Belcastro, Yimei Li, Daniel Martinez, Bruce Pawel, Stuart D. Shumway, John M. Maris, Kristina A. Cole

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361810035

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