Supplemental Figures S1-S11 from Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1-Mutant Breast Cancer
Year: 2023
Type: supplementary-materials
Abstract: S1. Ki67 and Cleaved Caspase-3 expression in mutant ER MBC. S2. Correlation of steroid hormone receptor expression in MBC. S3. Stable mutant ER cell line creation. S4. Steroid hormone receptor expression in T-47D and T-47D LTED cells. S5. Steroid hormone receptor expression of MCF-7 cells in suspension. S6. AR expression and inhibition in WT, D538G and Y537S T-47D cells. S7. Expression of steroid hormone receptors in mutant ER cells lines in 2D versus 3D culture. S8. Expression of CHI3L1, IFITM1 and IFITM3 in mutant ER cell lines from three different laboratories. S9. Mutual exclusivity of ESR1, TP53 and PIK3CA mutations in BC. S10. Tumor infiltrating immune cells in MBC stratified by TP53 and PIK3CA mutations. S11. PD-L1 expression in MBC stratified by tumor or stroma segmentation.
Authors: Michelle M. Williams, Nicole S. Spoelstra, Spencer Arnesen, Kathleen I. O'Neill, Jessica L. Christenson, Jordan Reese, Kathleen C. Torkko, Andrew Goodspeed, Emmanuel Rosas, Toru Hanamura, Sharon B. Sams, Zheqi Li, Steffi Oesterreich, Rebecca B. Riggins, Britta M. Jacobsen, Anthony Elias, Jason Gertz, Jennifer K. Richer
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361810611