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Supplementary Figure 1 from Dramatic Antitumor Effects of the Dual MET/RON Small-Molecule Inhibitor LY2801653 in Non–Small Cell Lung Cancer

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 62K, Figure S1. The protein tyrosine kinase activity profile obtained by using H1993 lysates treated with LY2801653 (10 nM) as tested on PamChip microarrays. For each of the 144 protein tyrosine kinase peptides on the array, treatment response was calculated as the log-transformed ratio of phosphorylation. 47 significant tyrosine kinase substrate modulation by LY2801653 (10 nM) treatment is shown (*: p-value <0.05, paired-two-tailed Student's t test).

DOI: 10.1158/0008-5472.22402431

Authors: Ichiro Kawada, Rifat Hasina, Qudsia Arif, Jeffrey Mueller, Erin Smithberger, Aliya N. Husain, Everett E. Vokes, Ravi Salgia

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361811267

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