Figure S1 from CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
Year: 2023
Type: other
Abstract: Transgenic murine glioma model possesses increased CD4+ and CD8+ T-cell infiltration early in tumor development. (A) Representative bioluminescence activity of tumor captured 21 and 35 days post-tumor induction (left). Scatter plot showing an example of an ex vivo flow cytometry of the brain tumors using the CD4+ and CD8+ markers (right). (B) Bioluminescence was measured at seven time points between 21 and 63 days post-tumor induction (n=8/time point). (C) Kaplan-Meier survival curve illustrating the time points of flow cytometric analysis relative to initiation of tumor-related death (n=16). (D) Bar plots showing CD4+ (left) and CD8+ (right) T-cell tumor infiltration normalized against the contralateral brain hemisphere, and bioluminescence signal at 21 and at 35 days post-tumor induction (n=16). Data in (D) is shown as mean {plus minus} SEM. p= 0.0189 and p= 0.026 by unpaired studentÂ's t-test.
Authors: Joshua R. Kane, Junfei Zhao, Takashi Tsujiuchi, Brice Laffleur, Víctor A. Arrieta, Aayushi Mahajan, Ganesh Rao, Angeliki Mela, Crismita Dmello, Li Chen, Daniel Y. Zhang, Edgar González-Buendia, Catalina Lee-Chang, Ting Xiao, Gerson Rothschild, Uttiya Basu, Craig Horbinski, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Peter Canoll, Adam M. Sonabend
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361815897