Supplementary Figures 1-10, Table 1 from Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 1.6MB, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal meningeal cells proliferate with a doubling time of about three days. S5. Ben-Men-1-LucB and parental Ben-Men-1 cells exhibit similar sensitivities to AR-42. S6. Intracranial NF2-deficient KT21-MG1 xenograft tumors demonstrated features of malignant meningiomas. S7. Ben-Men-1-LucB xenografts strongly expressed vimentin, amesenchymal marker for meningiomas. S8. AR-42 treatment caused tumor regression, whereas AR-12 treatment slowed tumor growth over time. S9. MRI detected a small tumor in a Ben-Men-1-LucB tumorbearing mouse treated with AR-42 for three months. S10. MRI did not detect the residual tumor in an AR-42-treated mouse after removal from AR-42 diet for six months.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361819702