Work

Supplementary Figures 1 - 2 from MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 2334K, SF1. Human P-gp is glycosylated in the LLC-PK1 cell line. SF2. Complete inhibition of drug efflux by P-gp wild-type and drug efflux of P-gp variants with high concentrations of a P-gp inhibitor.

DOI: 10.1158/0008-5472.22400631.v1

Authors: King Leung Fung, James Pan, Shinobu Ohnuma, Paul E. Lund, Jessica N. Pixley, Chava Kimchi-Sarfaty, Suresh V. Ambudkar, Michael M. Gottesman

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361819977

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