Supplemental Material and Methods, Figures 1 - 5 from An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 1 and Movie 1. Simulation images from the computational homeostatic basic multicellular unit (BMU) including parallel images of RANKL, TGFβ and bone derived factors including insulin like growth factor of the course of bone resorption and apposition. Supplemental Figure 2. Simulation images from the computational prostate tumorbone microenvironment model including parallel images of RANKL, TGFβ and bone derived factors of the course of 200 days. Supplemental Figure. 3. Plot shows that the behavior of the biological model (blue line) and computational model (black line) produce comparable outputs and show similar trends. Supplemental Figure 4. Determining the importance of MSC recruitment in the computational model. Supplemental Figure 5. Analysis of dosing efficacy in the computational model.
Language: English
Topic: Bone health and treatments
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361819983