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supplementary methods and figures from Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells

Year: 2023

Type: supplementary-materials

Abstract: File contains supplementary methods, primer sequences, supplementary figures and legends. Supplementary Figure S1 is the confirmation of p53-null status. Supplementary Figure S2 shows loss of Mdm2 induces a G2/M cell cycle arrest. Supplementary Figure S3 shows loss of Mdm2 induces a G2/M cell cycle arrest in vivo. Supplementary Figure S4 shows Mdm2 deletion induces apoptosis in vivo. Supplementary Figure S5 shows gene set enrichment analyses for apoptosis and p53 pathway genes.

Authors: Kyle P. Feeley, Clare M. Adams, Ramkrishna Mitra, Christine M. Eischen

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361820135

Cites: 6

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Related to: 10