Data from Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma
Year: 2023
Type: other
Abstract: Long noncoding RNAs (lncRNA) are emerging as a novel class of regulators in gene expression associated with tumorigenesis. However, the role of lncRNAs in papillary thyroid carcinoma (PTC) is poorly understood. Here, we conducted global lncRNA profiling and identified lncRNA AB074169 (lncAB) as significantly downregulated in PTC. Decreased expression of lncAB in PTC was caused by CpG hypermethylation within its gene promoter. Functional studies showed that lncAB overexpression led to cell-cycle arrest and tumor growth inhibition in vitro and in vivo, whereas lncAB knockdown promoted cell proliferation. Mechanistic analyses revealed that lncAB bound KH-type splicing regulatory protein (KHSRP) and also decreased expression of KHSRP, thus increasing CDKN1a (p21) expression and decreasing CDK2 expression to repress cell proliferation. Taken together, these findings demonstrate that lncAB functions as a tumor suppressor during PTC tumorigenesis. Significance: These findings identify a tumor-suppressive long noncoding RNA in papillary thyroid carcinoma. Graphical Abstract:http://cancerres.aacrjournals.org/content/canres/78/15/4163/F1.large.jpg. Cancer Res; 78(15); 4163–74. ©2018 AACR.
Authors: Qiheng Gou, Linbo Gao, Xinwen Nie, Wenchen Pu, Jingqiang Zhu, Yichao Wang, Xuesha Liu, Shuangyan Tan, Jian-Kang Zhou, Yanqiu Gong, Juan He, Ke Wu, Yuxin Xie, Wanjun Zhao, Lunzhi Dai, Lunxu Liu, Rong Xiang, Yu-Quan Wei, Lin Zhang, Yong Peng
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361824302