Work

Supplementary Data from Pharmacokinetic Profiles Determine Optimal Combination Treatment Schedules in Computational Models of Drug Resistance

Year: 2023

Type: supplementary-materials

Abstract: Supplemental data for the main manuscript. Contains equation description of the main features of the framework, description of the pharmacokinetic models and parameter estimates used for the simulations of the treatment effects, additional model fitting results and synergy/antagornism assesments, analysis of different dosing schedules and four different demos of the R package.

DOI: 10.1158/0008-5472.22426344.v1

Authors: Itziar Irurzun-Arana, Thomas O. McDonald, Iñaki F. Trocóniz, Franziska Michor

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361827501

Cites: 10

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Related to: 10