Work

Supplementary Figure 4 from Numb Regulates Stability and Localization of the Mitotic Kinase PLK1 and Is Required for Transit through Mitosis

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 150K, To determine if the changes seen in Plk1 stability were an indirect consequence of Numb's other roles we treated A375 cells with nonsense (NS) or Numb targeting shRNA in the presence of luciferase plasmids to measure the transcriptional activity of Notch (Hes-Luciferase), p53 (p21-Luciferase), or Hedgehog (Gli-Luciferase) signaling. Data is normalized to beta-galactosidase activity

DOI: 10.1158/0008-5472.22393268

Authors: Travis L. Schmit, Minakshi Nihal, Mary Ndiaye, Vijayasaradhi Setaluri, Vladimir S. Spiegelman, Nihal Ahmad

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W4361832639

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