Supplementary Figure 4 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 111K, Human Proneural tumors are relatively enriched in OPC genes. Expression profiles of 202 gliomas from TCGARN were analyzed, grouped into the four subclasses (2) A: Using gene symbol to map human and mouse homologues, highly significant enrichment of OPC genes in the human 'proneural' specific gene lists was identified (Chi-square p < 5E-31), but not in the other human glioma gene lists. Percent of tumor subclass specific gene lists overlapping with OPC specific genes. **** p<1E-32, + p<.06, Chi-square. All gene lists used pSI<.01 as a cut-off. B: Hierarchical clustering with just OPC genes is sufficient to distinguish most proneural tumors from other tumor subtypes. C: Expression level of average of OPC genes is higher in 'proneural' tumors though they are present at detectable levels in all subtypes. *p<.003, **p<.003, ***p<1E-7, ANOVA with Tukey Post Hocs.
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361833283