Work

Supplementary Figure 1 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 251K, (A) Left. C4-HD tumors growing with MPA were untreated or FUL-treated for 48 h and processed for immunohistochemical studies with pER� (Ser167 and Ser118) antibodies. Bar: 60�m. Right. Quantification of positive cells / HPF in untreated or FUL-treated C4-HD tumors. (B) Top. H&E images showing tumor morphology and Ki67 staining after treatment as described in (A). Black arrows show mitotic cells in MPA growing tumors. White arrows show apoptotic cells. Bar: 60�m. Right. Quantification of mitotic or apoptotic cells / HPF in untreated or FUL-treated C4-HD tumors. (C) BCL/XL, BAX and AIF expression after treatment as described in (A). Bar: 60�m.

DOI: 10.1158/0008-5472.22395527.v1

Authors: Sebastián Giulianelli, José P. Vaqué, Rocío Soldati, Victoria Wargon, Silvia I. Vanzulli, Rubén Martins, Eduardo Zeitlin, Alfredo A. Molinolo, Luisa A. Helguero, Caroline A. Lamb, J. Silvio Gutkind, Claudia Lanari

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361833709

Cites:

Cited by:

Related to: 10